FreedomFiler.com is the best home filing system. Plan to devote 5+ hours to get it set up, but then it is fabulous.

Create a separate Online Calendar for your children's activities and appointments. Google Calendar will allow you to have multiple calendars viewable on the same screen, so you can keep your work and personal appts separate from the kids'. Print the kids calendar each week and place on the fridge, give copies to Nanny, Daddy etc.

FlyLady.net If your house is always a mess you are living in CHAOS (Can't Have Anyone Over Syndrome.) While the website needs a visual overhaul, the content provides a good structure for getting into a clean routine.

National Association of Professional Organizers If you can afford some help, it is worth the investment. Even one day can dramatically improve your quality of life. (One friend had a professional come over for just 3 hours and re-do her desk. It changed her life.)